کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2611980 1134730 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Syndrome d'activation macrophagique d'origine infectieuse : étiologies et prise en charge
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی طب اورژانس
پیش نمایش صفحه اول مقاله
Syndrome d'activation macrophagique d'origine infectieuse : étiologies et prise en charge
چکیده انگلیسی
Hemophagocytic syndrome (HPS) is a rare and life-threatening disease. It is characterized by clinical criteria (fever, splenomegaly), biological features (cytopenias, low fibrinogen, high plasma triglycerids, and hyperferritinaemia) and pictures of hemophagocytosis within marrow, spleen or lymph nodes, caused by a dysregulation in cytokine secretion and activation and benign proliferation of lymphocytes or histiocytes. Among various aetiologies of HPS (primary genetic deficiency in children, haematological and solid malignancies, connective tissue disease), infection, most frequently by viruses, is an important one. The infectious agent responsible for HPS must be actively searched and promptly treated. Organ failures must be supported in an intensive care unit. An early administration of etoposide seems to be the cornerstone of HPS specific treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Réanimation - Volume 18, Issue 4, June 2009, Pages 284-290
نویسندگان
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