کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2612269 1134752 2007 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Encéphalomyélite aiguë disséminée et encéphalites post-infectieuses graves
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی طب اورژانس
پیش نمایش صفحه اول مقاله
Encéphalomyélite aiguë disséminée et encéphalites post-infectieuses graves
چکیده انگلیسی
Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disorder of the central nervous system (CNS). Also known as post-infectious encephalomyelitis, it typically follows a minor infection with a latency period of 2-30 days and is thought to be immune-mediated. ADEM is clinically characterized by the acute onset of focal neurological signs and encephalopathy. Patients can require intensive care unit admission because of encephalopathy, coma, seizures or tetraplegia. Cerebrospinal fluid analysis usually shows lymphocytic pleocytosis but, unlike viral or bacterial encephalitis, no evidence of direct CNS infection is found. There are no biologic markers of the disease and cerebral magnetic resonance imaging is essential to ADEM diagnosis, detecting diffuse or multifocal asymmetrical lesions throughout the white matter on T2- and FLAIR-weighted sequences. High-dose intravenous steroids are accepted as first-line ADEM therapy and several studies also reported beneficial effects of plasma exchanges and intravenous immunoglobulins. Outcome of ADEM patients is usually favorable but recurrent or multiphasic forms have been reported.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Réanimation - Volume 16, Issue 6, October 2007, Pages 452-462
نویسندگان
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