Intoxication grave par l'insuline

Severe acute insulin overdose is a rare poisoning that may be observed at all ages ranging from infants to elderly and even pregnant woman. Poisonings may be intentional, with or without suicidal attempt, factitious or felonious. Neurological findings, including restlessness coma, frequently with seizures are the common mode of presentation. However, focal neurological signs, psychiatric disorders, and even cardiovascular manifestations may delay the diagnosis and, consequently, the specific treatment. Both the severity and the prognostic factors of severe insulin poisonings are unknown. Treatment is mainly specific based on the administration of hypertonic dextrose as early as possible and during a long period of time. Repeated measurements of capillary glycemia allow the adaptation of dextrose infusion. Severe insulin poisoning is a cause of sustained coma, severe neurological sequelae, and death.