Doripénème dans les infections intra-abdominales

Doripenem has a spectrum of activity and pharmacokinetic characteristics close to those observed with other broad spectrum carbapenems : imipenem and meropenem. This agent could be recommended in the same circumstances, severe intra-abdominal infections and nosocomial infections. Tissular diffusion in the peritoneal exsudate is good. Prospective randomised studies assessing the efficacy of doripenem are scarce. In the pivotal study comparing doripenem to meropenem, clinical cure at the end of therapy was observed in similar proportions with the drugs (85.9 and 85.3%, respectively).