Manual and Manipulative Therapy in Addition to Rehabilitation for Osteoarthritis of the Knee: Assessor-Blind Randomized Pilot Trial

This pilot trial suggests that a confirmatory trial is feasible. There were significant changes in scores from baseline to week 5 across all groups, suggesting that all 3 treatment approaches may be of benefit to patients with mild-to-moderate knee OA, justifying a confirmatory trial to compare these interventions.