کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2655094 1139846 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nutritional Genomics, Polyphenols, Diets, and Their Impact on Dietetics
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Nutritional Genomics, Polyphenols, Diets, and Their Impact on Dietetics
چکیده انگلیسی

Nutritional genomics offers a way to optimize human health and the quality of life. It is an attractive endeavor, but one with substantial challenges. It encompasses almost all known aspects of science, ranging from the genomes of humans, plants, and microorganisms, to the highest levels of food science, analytical science, computing, and statistics of large systems, as well as human behavior. This paper describes the underlying biochemistry that is targeted by the principal issues in nutritional genomics, which entails genomics, transcriptomics, proteomics, and metabolomics. A major feature relevant to nutritional genomics is the single nucleotide polymorphisms in genes that interact with nutrients and other bioactive food components. These genetic changes may lead to alterations in absorption, metabolism, and functional responses to bioactive nutritional factors. Bioactive food components may also regulate gene expression at the transcriptome, protein abundance, and/or protein turnover levels. Even if all of these variables are known, additional variables to be considered include the nutritional variability of the food (unprocessed and processed), the amount that is actually eaten, and the eating-related behaviors of those consuming the food. These challenges are explored within the context of soy intake. Finally, the importance of international cooperation in nutritional genomics research is presented.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Dietetic Association - Volume 108, Issue 11, November 2008, Pages 1888–1895
نویسندگان
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