کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2666834 1140833 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical Guidance on the Use of Live Attenuated Influenza Vaccine After Inadvertent Freezing and Warming 1
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Clinical Guidance on the Use of Live Attenuated Influenza Vaccine After Inadvertent Freezing and Warming 1
چکیده انگلیسی

The immediate and long-term impact of temperature deviations that may occur in clinical practice on live attenuated influenza vaccine (LAIV) potency was examined in four distinct studies that exposed vaccine to freeze/thaw cycles, warming, and heating conditions. No significant loss of vaccine potency was observed after three freeze/thaw cycles, warming of vaccine to 15°C (59°F) for 72 hours or less, exposure to room temperature (25°C/77°F) for 12 hours or less, or after heating to 37°C (99°F) for 6 hours or less. The results of these studies demonstrate that LAIV potency can potentially be maintained after exposure to temperature deviations. If a particular annual formulation of LAIV is exposed to temperatures outside of the recommended storage range, practitioners should contact the manufacturer for guidance regarding proper vaccine handling.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pediatric Nursing - Volume 27, Issue 2, April 2012, Pages 163–167
نویسندگان
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