کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2673342 1141580 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hypoxic Ischemic Encephalopathy: Pathophysiology and Experimental Treatments
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Hypoxic Ischemic Encephalopathy: Pathophysiology and Experimental Treatments
چکیده انگلیسی

Hypoxic ischemic encephalopathy (HIE) is a serious birth complication affecting full-term infants; 40% to 60% of affected infants die by 2 years old or have severe disabilities. Most underlying pathologic events of HIE are a result of impaired cerebral blood flow and oxygen delivery to the brain with resulting primary and secondary energy failures. In the past, treatment options were limited to supportive medical therapy. Currently, several experimental treatments are being explored in neonates and animal models to ameliorate the effects of secondary energy failure. This review discusses the underlying pathophysiologic effects of a hypoxic-ischemic event and experimental treatment modalities being explored to manage infants with HIE. Further research is needed to better understand if the long-term impact of the experimental treatments and whether the combinations of experimental treatments can improve outcomes of infants with HIE.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Newborn and Infant Nursing Reviews - Volume 11, Issue 3, September 2011, Pages 125–133
نویسندگان
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