Oral Agents in Cancer Treatment: The Context for Adherence

ObjectivesTo review oral agents approved for cancer, discuss their mechanism of action and/or molecular targets, and outline side effects and challenges that impact adherence.Data SourcesPeer reviewed literature and on-line drug information.ConclusionOral agents to treat cancer, although not new, are common and increasing dramatically. The context of adherence to oral agents is complicated by increased knowledge of food-drug interactions and combinations of agents with overlapping or synergistic toxicity profiles.Implications for Nursing PracticeThe role of nursing in the administration and education of oral cancer treatments is critical to optimal treatment outcomes.