Germline Mutations in Cancer Susceptibility Genes: An Overview for Nurses

ObjectiveTo provide an overview of hereditary cancer susceptibility genes and associated cancer risks.Data SourcesPeer reviewed published research studies and review articles.ConclusionsIdentifying deleterious mutations in cancer susceptibility genes allows for clarification of cancer risk in individual family members and risk-level appropriate screening, and risk management recommendations. Evolving knowledge of the role of germline mutations provides an unprecedented opportunity to reduce cancer incidence, morbidity, and morality.Implications for Nursing PracticeTo provide individuals/families with accurate cancer risk management information and guidance, oncology nurses must be familiar with scientific discoveries related to cancer susceptibility genes.