Cytoprotective Agents Used in the Treatment of Patients With Cancer

ObjectiveTo provide a review of the literature of commonly prescribed cytoprotective agents used in the treatment of patients with cancer.Data SourcesJournal articles, research reports, review articles, and web sites.ConclusionMultiple agents have been theorized to have cytoprotective properties. Significant evidence exists supporting the use of some cytoprotective agents approved by the US Food and Drug Administration (FDA). More research is needed to determine the efficacy of new cytoprotective agents and expanded indications for those agents currently used.Implications for Nursing PracticeKnowledge of the indications for and side effect profiles of cytoprotective agents is a necessary component of oncology nursing care. Familiarity with evidence-based research that supports or refutes the use of FDA-approved cytoprotective agents or alternative agents is helpful when suggesting, prescribing, or administering such agents.