کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2691652 1143371 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antiviral activity of Chongkukjang extracts against influenza A virus in vitro and in vivo
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Antiviral activity of Chongkukjang extracts against influenza A virus in vitro and in vivo
چکیده انگلیسی

BackgroundChongkukjang is a traditional Korean fermented product prepared from soybeans and reported to have multiple biological functions, including antidiabetic, antiinflammatory, and neuroprotective effects. Influenza is a respiratory disease caused by influenza viruses and continues to be a worldwide threat with a high potential to cause pandemics. Besides vaccination, only two classes of drugs are available for antiviral treatment against these pathogens.MethodsWe tested the inhibitory activity of an ethyl acetate extract from Chongkukjang toward influenza A virus neuraminidase.ResultsAll 10 compounds extracted from Chongkukjang showed neuraminidase inhibitory activity. Extracts A3 and A8, with high neuraminidase content, had the best inhibitory activities. The in vivo antiinfluenza virus activities of the ethyl acetate, A3, and A8 extracts as well as commercially available genistein were evaluated using H1N1 (A/NWS/33) to test mice survivability after virus challenge. The Chongkukjang extracts did not reduce mortality, but the A3 and A8 extracts delayed the median time to death after influenza A virus infection of mice.ConclusionOur results suggest that the Chongkukjang extracts may have potential as a therapeutic agent to treat influenza virus infection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnic Foods - Volume 2, Issue 2, June 2015, Pages 47–51
نویسندگان
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