کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2691799 | 1143388 | 2014 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Acides gras polyinsaturés oméga 3 et toxicité hépatique de l'éthanol : rôle du remodelage membranaire
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Acides gras polyinsaturés oméga 3 et toxicité hépatique de l'éthanol : rôle du remodelage membranaire Acides gras polyinsaturés oméga 3 et toxicité hépatique de l'éthanol : rôle du remodelage membranaire](/preview/png/2691799.png)
چکیده انگلیسی
Alcoholic liver disease is characterized by an early development of steatosis that can progress to steatohepatitis or cirrhosis, but only for 20% of heavy drinkers. Nowadays, description of risk factors and of cellular and molecular mechanisms involved in the disease pathogenesis still remains incomplete. These last years, the plasma membrane microstructures called lipid rafts, were described as a new target for ethanol. Besides, n-3 polyunsaturated fatty acids, naturally present in fat fish, were reported to be able to modulate physically and chemically the lipid raft microenvironment, with beneficial effects towards inflammation or cancer. In this context, the aim of the present review was to establish a link between omega 3-induced membrane alterations and their effects on the molecular mechanisms involved in alcoholic liver disease pathogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition Clinique et Métabolisme - Volume 28, Issue 1, February 2014, Pages 17-28
Journal: Nutrition Clinique et Métabolisme - Volume 28, Issue 1, February 2014, Pages 17-28
نویسندگان
Odile Sergent, Normand Podechard, Fatiha Aliche-Djoudi, Dominique Lagadic-Gossmann,