کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2693037 1143495 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analysis of release kinetics of ocular therapeutics from drug releasing contact lenses: Best methods and practices to advance the field
ترجمه فارسی عنوان
تجزیه و تحلیل سینتیک آزادی درمان های چشم از لنزهای تماسی دارویی: بهترین روش ها و شیوه های پیشگیری از این زمینه
کلمات کلیدی
جنبش آزاد سینک کامل، انتشار کنترل شده، درمان های چشمی، لنز طبی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی چشم پزشکی
چکیده انگلیسی

Several methods have been proposed to achieve an extended and controlled release of ocular therapeutics via contact lenses; however, the experimental conditions used to study the drug release vary greatly and significantly influence the release kinetics. In this paper, we examine variations in the release conditions and their effect on the release of both hydrophilic and hydrophobic drugs (ketotifen fumarate, diclofenac sodium, timolol maleate and dexamethasone) from conventional hydrogel and silicone hydrogel lenses. Drug release was studied under different conditions, varying volume, mixing rates, and temperature. Volume had the biggest effect on the release profile, which ironically is the least consistent variable throughout the literature. When a small volume (2–30 mL) was used with no forced mixing and solvent exchange every 24 h, equilibrium was reached promptly much earlier than solvent exchange, significantly damping the drug release rate and artificially extending the release duration, leading to false conclusions. Using a large volume (200–400 mL) with a 30 rpm mixing rate and no solvent exchange, the release rate and total mass released was significantly increased. In general, the release performed in small volumes with no force mixing exhibited cumulative mass release amounts of 3–12 times less than the cumulative release amounts in large volumes with mixing. Increases in mixing rate and temperature resulted in relatively small increases of 1.4 and 1.2 times, respectively in fractional mass released. These results strongly demonstrate the necessity of proper and thorough analysis of release data to assure that equilibrium is not affecting release kinetics. This is paramount for comparison of various controlled drug release methods of therapeutic contact lenses, validation of the potential of lenses as an efficient and effective means of drug delivery, as well as increasing the likelihood of only the most promising methods reaching in vivo studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Contact Lens and Anterior Eye - Volume 37, Issue 4, August 2014, Pages 305–313
نویسندگان
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