کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2695506 1565013 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Wakayama Symposium: Peroxisome Proliferator-Activated Receptor-Gamma (PPARγ) and Meibomian Gland Dysfunction
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی چشم پزشکی
پیش نمایش صفحه اول مقاله
Wakayama Symposium: Peroxisome Proliferator-Activated Receptor-Gamma (PPARγ) and Meibomian Gland Dysfunction
چکیده انگلیسی

Recently we have shown that mouse and human meibomian glands undergo specific age-related changes, including decreased acinar cell proliferation, acinar atrophy, and altered peroxisome proliferator-activated receptor gamma (PPARγ) localization from cytoplasmic-vesicular/nuclear in young mice and humans to nuclear in old mice and humans. Since PPARγ is a lipid-sensitive, nuclear receptor implicated in regulating adipocyte and sebocyte differentiation and lipogenesis, our findings suggest that PPARγ may be involved in modulating meibomian gland differentiation during aging. Based on these findings, we propose that aging of the meibomian gland results in downregulation of PPARγ, leading to decreased meibocyte differentiation and lipid synthesis, gland atrophy, and a hyposecretory meibomian gland dysfunction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Ocular Surface - Volume 10, Issue 4, October 2012, Pages 224–229
نویسندگان
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