کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2703992 1144667 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Carotid Artery Stiffness in Patients with Symptomatic Carotid Artery Disease with Contralateral Asymptomatic Carotid Artery Disease and in Patients with Bilateral Asymptomatic Carotid Artery Disease: A Cine Phase-contrast Carotid MR Study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مغز و اعصاب بالینی
پیش نمایش صفحه اول مقاله
Carotid Artery Stiffness in Patients with Symptomatic Carotid Artery Disease with Contralateral Asymptomatic Carotid Artery Disease and in Patients with Bilateral Asymptomatic Carotid Artery Disease: A Cine Phase-contrast Carotid MR Study
چکیده انگلیسی

BackgroundAtherosclerosis is a systemic inflammatory disease that may affect multiple arterial beds simultaneously. Vascular distensibility is increasingly used in the clinical assessment of patients with atherosclerotic disease. In this study, we assess distensibility of symptomatic atherosclerotic carotid artery and of contralateral asymptomatic side. We also investigate the distensibility of bilaterally asymptomatic atherosclerotic carotid arteries using cine phase-contrast carotid magnetic resonance (MR) imaging.MethodsNineteen patients with bilateral carotid artery disease underwent cine phase-contrast carotid imaging on a 1.5 T MR system. Ten patients had ipsilateral symptomatic carotid artery disease and contralateral asymptomatic stenosis. Nine additional patients with bilateral asymptomatic carotid artery disease constituted historical control group. Cine phase-contrast MR imaging acquired at the common carotid artery, maximum luminal stenosis, and internal carotid artery was used to determine carotid distensibility bilaterally for carotid arteries in both patient groups.ResultsSymptomatic carotid arteries were found to be significantly less distensible (mean distensibility coefficient [DC] 35.4 ± 6.12 × 10−3/kPa) than the contralateral asymptomatic vessels (mean DC 54.4 ± 7.88 × 10−3/kPa, P = .03) at the level of the common carotid artery. A similar trend of high distensibility for asymptomatic side in the area of maximum stenosis and the internal carotid artery was seen, but it was not found to be statistically significant. Plaque burden was comparable between the 2 groups at all locations. DC was comparable for patients with bilateral asymptomatic carotid artery stenoses. Distensibility of bilaterally asymptomatic carotid arteries was greater than that of asymptomatic carotid artery contralateral to the symptomatic side.ConclusionsSymptomatic carotid artery is stiffer than the contralateral asymptomatic side, despite comparable plaque burden. Patients with bilateral asymptomatic carotid artery disease have comparable stiffness. Larger studies are warranted to further investigate the findings of this MR study.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Stroke and Cerebrovascular Diseases - Volume 23, Issue 4, April 2014, Pages 743–748
نویسندگان
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