Migraine Improves after Ischemic Stroke

Ischemic stroke is very often followed by a marked and persistent improvement of prestroke migraine. The causes of improvement are unclear and may involve changes in lifestyle and psychological status, drugs, platelet activation, or modifications of vasoreactivity after stroke. These data suggest that studies reporting the efficacy of PFO closure for migraine in stroke patients are probably biased by the lack of a control group.