کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2716948 1145365 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Folic Acid Supplementation Improves Vascular Function in Professional Dancers With Endothelial Dysfunction
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ارتوپدی، پزشکی ورزشی و توانبخشی
پیش نمایش صفحه اول مقاله
Folic Acid Supplementation Improves Vascular Function in Professional Dancers With Endothelial Dysfunction
چکیده انگلیسی

ObjectiveTo determine if folic acid supplementation improves vascular function (brachial artery flow-mediated dilation [FMD]) in professional dancers with known endothelial dysfunction.DesignProspective cross-sectional study.SettingAcademic institution in the Midwestern United States.SubjectsTwenty-two professional ballet dancers volunteered for this study.Main Outcome MeasuresSubjects completed a 3-day food record to determine caloric and micronutrient intake. Menstrual status was determined by interview and questionnaire. Endothelial function was determined as flow-induced vasodilation measured by high-frequency ultrasound of the brachial artery. A change in brachial diameter of <5% to hyperemic flow stimulus was defined a priori as endothelial dysfunction. Subjects with abnormal FMD took 10 mg of folic acid daily for 4 weeks, and FMD testing was then repeated. Serum whole blood was measured for folic acid levels before and after supplementation.ResultsSixty-four percent of dancers (n = 14) had abnormal brachial artery FMD (<5%) (mean ± standard deviation, 2.9% ± 1.5%). After 4 weeks of folic acid supplementation (10 mg/day), FMD improved in all the subjects (7.1% ± 2.3%; P < .0001).ConclusionsThis study reveals that vascular endothelial function improves in dancers after supplementation with folic acid (10 mg/day) for at least 4 weeks. This finding may have clinically important implications for future cardiovascular disease risk prevention.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: PM&R - Volume 3, Issue 11, November 2011, Pages 1005–1012
نویسندگان
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