کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2719074 | 1566172 | 2011 | 4 صفحه PDF | دانلود رایگان |

BackgroundTako-Tsubo cardiomyopathy (TTC) is a heart syndrome associated with transient myocardial contractile dysfunction. The pathogenesis of TTC remains unclear. The purpose of this study was to investigate brachial artery flow-mediated dilation (FMD) in patients with TTC.MethodsThe results of FMD tests of 4 women with TTC were compared with the results from 18 women with ST-elevation acute myocardial infarction (STEMI) and from 26 healthy female volunteers. FMD tests in all patients were performed within 24 hours of admission and again at 1-3 weeks as a follow-up.ResultsThe FMD levels were significantly lower at the acute phase in patients with TTC than in patients with STEMI and in healthy volunteers (P <.01). After 1-3 weeks, the FMD test results of patients with TTC had greatly increased, and no significant differences were found between these results and the results from patients with STEMI (P >.05). Also, there were no significant differences in the FMD test results between the group of patients with TTC and the group of healthy volunteers (P >.05).ConclusionsThere is a pronounced and reversible endothelial dysfunction in patients with TTC, which can impair myocardial perfusion.
Journal: The American Journal of Medicine - Volume 124, Issue 12, December 2011, Pages 1176–1179