Pedal Squamous Cell Carcinoma in an Immunocompromised Host

Squamous cell carcinoma is a well-known and prevalent form of skin cancer. Although commonly associated with areas of increased sun exposure, squamous cell carcinoma can also localize to the foot. Immunocompromised patients are also at an increased risk of developing squamous cell carcinoma, in comparison to individuals with a fully intact immune system. Furthermore, individuals with a history of human papilloma virus infection are at a heightened risk for developing squamous cell carcinoma, particularly in regard to the development of lower extremity lesions. In this report, we discuss the epidemiology and diagnosis of squamous cell carcinoma, and we describe the case of an immunocompromised patient with multiple medical comorbidities who presented with squamous cell carcinoma involving his left foot. The patient underwent surgical excision of the skin lesion, and histopathological analysis of the lesion was undertaken. Further research is needed in an effort to identify specific human papilloma virus genotypes and quantitative measurements of immune competence, in order to better serve clinicians and surgeons in the management of squamous cell carcinoma. Level of Clinical Evidence: 4