کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2724400 1146146 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel Patch for Transdermal Administration of Morphine
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Novel Patch for Transdermal Administration of Morphine
چکیده انگلیسی

ContextTransdermal absorption of morphine into the systemic circulation through intact skin has not been reported.ObjectivesTo describe a novel transdermal formulation for a morphine hydrochloride patch consisting of polyethylene sponge foam as the retaining agent and adjusted proportions of morphine hydrochloride and adjunctive drugs.MethodsIn this study, the transdermal morphine hydrochloride patch was administered to intact skin in five subjects and the plasma concentrations of morphine and its metabolites were examined.ResultsMorphine was absorbed systemically, producing plasma morphine concentrations above the assay detection limit by at least 24 hours after attachment of patches containing a total dose of 180 mg of morphine. The levels gradually increased in a time-dependent manner without serious events. The area under the concentration-time curve from 0 to 72 hours (AUC0–72) values for morphine, morphine-6-glucuronide, and morphine-3-glucuronide were 60.4 ± 13.4, 133.7 ± 17.4, and 861.5 ± 126.7 ng·h/mL, respectively. The mean plasma area under the concentration-time curve from 0 to 72 hours ratio for morphine-6-glucuronide relative to morphine was 2.64.ConclusionThese data provide useful information for developing a transdermal morphine system.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pain and Symptom Management - Volume 44, Issue 4, October 2012, Pages 479–485
نویسندگان
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