کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2725226 | 1566260 | 2007 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Effective Pharmacologic Management of Alzheimer’s Disease Effective Pharmacologic Management of Alzheimer’s Disease](/preview/png/2725226.png)
In order to assist physicians in the effective pharmacologic management of this challenging population, evidence-based pharmacologic treatment algorithms for the different stages of Alzheimer’s disease have been developed. Evidence-based guidelines outlining pharmacotherapeutic strategies can be systematically implemented to optimize outcomes for patients in different stages of Alzheimer’s disease. The first step toward the best possible long-term management is early diagnosis of Alzheimer’s disease, thereby facilitating early initiation of cholinesterase inhibitor treatment, which may stabilize/reduce the rate of symptomatic cognitive and functional decline. Cholinesterase inhibitor therapy with rivastigmine, donepezil, or galantamine is endorsed as standard first-line therapy in patients with mild-to-moderate Alzheimer’s disease. The N-methyl-D-aspartate receptor-antagonist, memantine, may be used as monotherapy or in combination with a cholinesterase inhibitor for patients with moderate Alzheimer’s disease, and as monotherapy for patients with severe Alzheimer’s disease. During treatment, cognitive and functional status should be monitored over 6-month intervals, and pharmacologic therapy should ideally be continued until there are no meaningful social interactions and quality of life has irreversibly deteriorated.
Journal: The American Journal of Medicine - Volume 120, Issue 5, May 2007, Pages 388–397