کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2726591 1146525 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular Markers in Low-Grade Glioma—Toward Tumor Reclassification
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Molecular Markers in Low-Grade Glioma—Toward Tumor Reclassification
چکیده انگلیسی

Low-grade diffuse gliomas are a heterogeneous group of primary glial brain tumors with highly variable survival. Currently, patients with low-grade diffuse gliomas are stratified into risk subgroups by subjective histopathologic criteria with significant interobserver variability. Several key molecular signatures have emerged as diagnostic, prognostic, and predictor biomarkers for tumor classification and patient risk stratification. In this review, we discuss the effect of the most critical molecular alterations described in diffuse (IDH1/2, 1p/19q codeletion, ATRX, TERT, CIC, and FUBP1) and circumscribed (BRAF-KIAA1549, BRAFV600E, and C11orf95-RELA fusion) gliomas. These molecular features reflect tumor heterogeneity and have specific associations with patient outcome that determine appropriate patient management. This has led to an important, fundamental shift toward developing a molecular classification of World Health Organization grade II-III diffuse glioma.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Radiation Oncology - Volume 25, Issue 3, July 2015, Pages 155–163
نویسندگان
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