کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2728621 1566749 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Second Messengers Mediating the Expression of Neuroplasticity in a Model of Chronic Pain in the Rat
ترجمه فارسی عنوان
پیامبران دوم، بیانگر بیان عصب پلاستیکی در یک مدل درد مزمن در موش صحرایی است
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی

Hyperalgesic priming is a model of the transition from acute to chronic pain, in which previous activation of cell surface receptors or direct activation of protein kinase C epsilon markedly prolongs mechanical hyperalgesia induced by pronociceptive cytokines. We recently demonstrated a role of peripheral protein translation, alpha-calmodulin-dependent protein kinase II (αCaMKII) activation, and the ryanodine receptor in the induction of hyperalgesic priming. In the present study, we tested if they also mediate the prolonged phase of prostaglandin E2–induced hyperalgesia. We found that inhibition of αCaMKII and local protein translation eliminates the prolonged phase of prostaglandin E2 hyperalgesia. Although priming induced by receptor agonists or direct activation of protein kinase C epsilon occurs in male but not female rats, activation of αCaMKII and the ryanodine receptor also produces priming in females. As in males, the prolonged phase of prostaglandin E2–induced hyperalgesia in female rats is also protein kinase C epsilon–, αCaMKII-, and protein translation–dependent. In addition, in both male and female primed rats, the prolonged prostaglandin E2–induced hyperalgesia was significantly attenuated by inhibition of MEK/ERK. On the basis of these data, we suggest that the mechanisms previously shown to be involved in the induction of the neuroplastic state of hyperalgesic priming also mediate the prolongation of hyperalgesia.PerspectivesThe data provided by this study suggest that direct intervention on specific targets may help to alleviate the expression of chronic hyperalgesic conditions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Pain - Volume 15, Issue 3, March 2014, Pages 312–320
نویسندگان
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