Cytokine Profiles During Carrageenan-Induced Inflammatory Hyperalgesia in Rat Muscle and Hind Paw

The quality and mechanisms of muscle pain are different from that of cutaneous pain. So too is the pattern of cytokine release during inflammation. Inhibiting TNF-α is unlikely to be effective in managing inflammatory muscle pain, but other cytokines, notably IL-1β and CINC-1, may prove useful therapeutic targets.