The Identification of Plasma Proteins Associated With Cancer-Related Fatigue Syndrome (CRFS) in Disease-Free Breast Cancer Patients Using Proteomic Analysis

These novel results (using a technique not previously used in fatigue research) add further weight to the hypothesis that CRFS may be precipitated and prolonged by a nonspecific sustained inflammatory response. Importantly, this has been identified from a global analysis of plasma, which was conducted with no prior assumptions. Although these results need confirmation, we would suggest that future treatments for CRFS should consider focusing on the modulation of this presumed prolonged immune response.