کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2735150 1147699 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Amitriptyline in the Treatment of Chemotherapy-Induced Neuropathic Symptoms
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Amitriptyline in the Treatment of Chemotherapy-Induced Neuropathic Symptoms
چکیده انگلیسی

Neuropathy is common in patients receiving vinca alkaloids, platinum derivatives, or taxanes. This double-blind, randomized, placebo-controlled study assessed the efficacy of low-dose amitriptyline to relieve chemotherapy-induced symptoms in 44 patients (age 20–65 years) who had neuropathic symptoms (numbness, tingling, pain) with a severity of ≥3/10. They were treated with amitriptyline for eight weeks (10 mg/day to start, then dose elevation of 10 mg/week up to 50 mg/day if tolerated, followed by a stable dose ≥4 weeks). The patients completed a diary twice weekly, noting the intensity of pain, numbness and tingling, global improvement, and adverse effects. Neurological examination was performed at each visit (baseline, four, and eight weeks). The patients assessed both intensity and relief of pain, and overall discomfort. They also completed the Neuropathic Pain Scale and validated measures of anxiety and depression, and quality of life (QoL). The results demonstrated that amitriptyline did not improve sensory neuropathic symptoms, although there was a trend toward global improvement and improved QoL in favor of the amitriptyline group. No statistical significance was reached, probably due to the small number of patients and too low dose of amitriptyline. Amitriptyline was well tolerated.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pain and Symptom Management - Volume 35, Issue 1, January 2008, Pages 31–39
نویسندگان
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