کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2735584 1404109 2016 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Success and Failures of Combined Modalities in Glioblastoma Multiforme: Old Problems and New Directions
ترجمه فارسی عنوان
موفقیت و شکست ترکیبی مدالیتی در گلیوبلاستوما مولتی: مشکلات قدیمی و دستورالعمل های جدید
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی

Glioblastoma multiforme (GBM) is an aggressive intracranial tumor characterized by local and distant brain relapse despite aggressive therapy. Current standard treatment includes surgical resection followed by radiation with concurrent and adjuvant temozolomide as part of a combined modality approach. In this review, the historical basis for the current standard treatment is discussed as well as other recent combined modality successes and failures. An overview of emerging combined modality therapies for GBM is presented including immunotherapy, and rationally designed radiosensitizers. Unanswered questions facing the oncology community regarding the treatment of GBM are also discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Radiation Oncology - Volume 26, Issue 4, October 2016, Pages 281–298
نویسندگان
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