کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2742496 1148610 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A simplified bedside approach to acid–base: fluid physiology utilizing classical and physicochemical approaches
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
A simplified bedside approach to acid–base: fluid physiology utilizing classical and physicochemical approaches
چکیده انگلیسی

The quantitative physicochemical model of human acid–base physiology filled a void that had developed between clinical acid–base analysis and general fluid physiology. Established approaches centred on the Henderson–Hasselbach (HH) equation allow a satisfactory exploration of respiratory perturbations but do not fully elucidate mechanisms of common non-respiratory ‘metabolic’ components. Though useful at the bedside, commonly used ‘rules of thumb’ that classify disturbances based on quantification of bicarbonate relative to CO2 have also fostered a language that often misrepresents bicarbonate physiology.The physicochemical model is frequently perceived as too complex for bedside use, however a set of simplified screening questions based on Stewart's model can be utilized to aid acid–base interpretation. Examples using this approach are included in an online appendix. Emphasis is placed on understanding the consequences of hypoalbuminaemia, volume, tonicity and chloride derangements as these are common in the care of intensive care unit patients. Aetiologies of acid–base disturbances are well described elsewhere and are not repeated here.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Anaesthesia & Intensive Care Medicine - Volume 14, Issue 10, October 2013, Pages 445–452
نویسندگان
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