کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2754246 1149764 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Higher Infection Rate After 7- Compared With 5-Day Cycle of Azacitidine in Patients With Higher-Risk Myelodysplastic Syndrome
ترجمه فارسی عنوان
نرخ عفونت بالا بعد از 7 سال در مقایسه با چرخه 5 روزه آزاتیوتییدین در بیماران مبتلا به سندرم ملودی پلاسمایی با خطر بالاتری
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
چکیده انگلیسی

IntroductionAzacitidine (AZA) dose reduction is a common practice in cytopenic patients. However, a correlation between AZA dose and infection complications has never been studied.Patients and MethodsHigher-risk patients with myelodysplastic syndrome or acute myeloid leukemia treated with AZA in 18 Israeli hospitals between the years 2008 and 2011 were included in a former national survey. To reveal the effect of AZA dosage on infection risk we limited our analysis to the infection rate after the first AZA dose alone. We excluded subsequent cycles of AZA from the analysis, because infectious events during these cycles might be related to other cofactors such as disease response to AZA therapy.ResultsAfter the first AZA cycle, infectious events were more frequent after doses of 75 mg/m2 for 7 days than 75 mg/m2 for 5 days (36/106 [34%] and 10/67 [14.9%], respectively; P = .008), regardless of the patient's age. Of the 46 recorded infectious events, the causative pathogen was identified as bacterial in 25 (54.3%) and as viral or fungal in 2 (4.3%) and 2 (4.3%) cases, respectively. No pathogen was identified in 17 (37%) cases. Infections were significantly more prevalent among patients who presented with platelet counts < 20,000 (43.6% vs. 23.6%; P = .012) and poor risk cytogenetics (40.7% vs. 19.8%; P = .008).ConclusionReduction of AZA dose might decrease infection rate and therefore should be considered in patients with high infection risk.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Lymphoma Myeloma and Leukemia - Volume 15, Issue 6, June 2015, Pages e95–e99
نویسندگان
, , , , , , , , , , , , , , , ,