کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2754599 1149789 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Bone Marrow Microenvironment in Waldenström Macroglobulinemia
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
The Bone Marrow Microenvironment in Waldenström Macroglobulinemia
چکیده انگلیسی

Waldenström macroglobulinemia (WM) is a lymphoplasmacytic lymphoma characterized by widespread involvement of the bone marrow (BM). The BM microenvironment serves as not only a site for disease involvement, but it also appears that the interaction of WM cells with the BM is essential for the pathogenesis of WM. The BM microenvironment consists of the cellular and noncellular compartments. The BM has been shown to regulate cell proliferation, cell cycle, and drug resistance as well as cell dissemination and cell trafficking of WM cells. A better understanding of the role of the BM microenvironment in the pathogenesis of WM can help guide better therapeutic strategies that can target the tumor clone and also regulate the BM microenvironment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Lymphoma Myeloma and Leukemia - Volume 13, Issue 2, April 2013, Pages 218–221
نویسندگان
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