کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2755100 1149806 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Associated Malignancies in Patients with Waldenström's Macroglobulinemia and Their Kin
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
Associated Malignancies in Patients with Waldenström's Macroglobulinemia and Their Kin
چکیده انگلیسی

We examined the incidence of other malignancies in 924 Waldenström's Macroglobulinemia (WM) patients and their kin. A total of 225 (24.3%) patients had ≥ 1 additional malignancy, with 63% predating the WM diagnosis. The most common gender-adjusted malignancies were prostate (9.4%), breast (8.0%), non-melanoma skin (7.1%), hematologic (2.8%), melanoma (2.2%), lung (1.4%) and thyroid 1.1%). Among hematologic malignancies, all 13 cases of diffuse large B-cell lymphoma and 4 cases of acute myelogenous leukemia were diagnosed after WM, and were therapy-related. Familial WM subgroup analysis showed a higher incidence of prostate cancer (P = .046) in sporadic WM patients, while patients with familial WM had a higher incidence of lung cancer (P = .0043). An increased incidence of myeloid leukemias (P < .0001) was reported among kin of familial WM patients. These data reveal specific cancer associations with WM, and provide a basis for exploratory studies aimed at delineating a common genetic basis. Additionally, these studies suggest specific cancer clustering based on familial predisposition to WM.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Lymphoma Myeloma and Leukemia - Volume 11, Issue 1, February 2011, Pages 88–92
نویسندگان
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