کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2755126 1149806 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Heterogeneity of Histological Transformation Events in Waldenström's Macroglobulinemia (WM) and Related Disorders
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
Heterogeneity of Histological Transformation Events in Waldenström's Macroglobulinemia (WM) and Related Disorders
چکیده انگلیسی

Histological transformation, typically to diffuse large B-cell lymphoma (DLBCL) is reported to occur in 5%-10% of patients with WM and recent studies have highlighted a possible aetiological role for the nucleoside analogues. It is however becoming increasingly clear that histological transformation is a complex phenomenon and may include clonally unrelated disorders. In order to highlight this pathological heterogeneity we describe 5 patients with diverse histological progression events. These included EBV-associated events namely DLBCL, peripheral T-cell lymphoma and spontaneously resolving mucocutaneous ulcer. A further 2 patients demonstrated a localised plasma cell rich lesion simulating plasmacytoma and a de novo DLBCL arising in an unrelated B-cell clone. It is clear therefore that detailed pathological assessments are required in all suspected cases of transformation and that the pathological heterogeneity demonstrated by this study needs to be taken into account when potential aetiological factors are being assessed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Lymphoma Myeloma and Leukemia - Volume 11, Issue 1, February 2011, Pages 176–179
نویسندگان
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