Ribosomal Protein Metallopanstimulin-1 Impairs Multiple Myeloma CAG Cells Growth and Inhibits Fibroblast Growth Factor Receptor 3

IntroductionIt was demonstrated that metallopanstimulin-1 (MPS-1, RPS27) inhibited the growth of tumors formed by head and neck squamous cell carcinoma cells and reduced paxillin gene expression.MethodsThe present study examined whether and how MPS-1 affects another type of cancer, multiple myeloma (CAG). Enhanced expression of MPS-1 dramatically inhibited CAG in vitro and in vivo.ResultsOverexpression of MPS-1 resulted in decreased fibroblast growth factor (FGF2) receptor 3 and impaired endogenous MAPK/ErK signaling. MAPK/ErK signaling was not stimulated by adding recombinant FGF2 to myeloma cells overexpressing MPS-1.ConclusionsThese data suggest that MPS-1 suppresses CAG growth and that weakened FGF2 signaling may contribute to this effect.