کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2755260 1149811 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Changes Associated With Lenalidomide Treatment in the Gene Expression Profiles of Patients With Del(5q)
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
Changes Associated With Lenalidomide Treatment in the Gene Expression Profiles of Patients With Del(5q)
چکیده انگلیسی

BackgroundLenalidomide is an effective treatment for patients with del(5q) and myelodysplastic syndrome (MDS) The exact mechanism of lenalidomide function and its impact on the prognosis of patients is not known exactly.Materials and MethodsWe used gene expression profiling to study the effect of lenalidomide therapy in peripheral blood CD14+ monocytes of 6 patients with del(5q) and MDS.ResultsAfter lenalidomide treatment, genes involved in the tumor necrosis factor (TNF) signaling pathway that were upregulated in the patients before treatment decreased to the healthy control baseline expression level. This change in gene expression, in conjunction with increased expression of repressed genes that affect the stem cell niche (ie, CXCR4 and CRTAP), may exert a positive effect on treated patients. In contrast, we found that increased expression of the ARPC1B gene may have a negative impact on the stability of patient remission.ConclusionThe observed changes in gene expression described here may contribute to the identification of pathways that are affected by lenalidomide, which may help to explain the effects of this drug.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Lymphoma Myeloma and Leukemia - Volume 12, Issue 5, October 2012, Pages 375–383
نویسندگان
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