کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2756121 1567408 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparative study between transdermal fentanyl and melatonin patches on postoperative pain relief after lumber laminectomy, a double-blind, placebo-controlled trial
ترجمه فارسی عنوان
بررسی مقایسه ای بین تکه های فنتانیل ترادرمانی و ملاتونین در تسکین درد پس از عمل بعد از لامینکتومی چوب، یک مطالعه دو سوکور، کنترل دارونما
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
چکیده انگلیسی

BackgroundThis study evaluated the efficacy of transdermal fentanyl (TDF) delivery system (50 μg/h) or transdermal melatonin (TDM) delivery system (7 mg) 2 h preoperatively for acute postoperative pain after lumbar laminectomy compared to placebo group (C).MethodsSeventy-five patients of both sexes, aged 18–50 years, ASA I and II undergoing elective single level lumber laminectomy under general anesthesia were included in this randomized controlled double-blind study. Patients were randomly divided into 3 groups 25 each, C group patients received transdermal placebo patch, TDF group (50 μg/h) and TDM group (7 mg). Assessment of postoperative pain, sedation, hemodynamic variables such as HR and MAP, postoperative monitoring of arterial SpO2 and side effects (e.g. nausea, vomiting, pruritis, respiratory depression and hemodynamic instability) was done 30 min, 1, 2, 6 and 12 h postoperatively. Postoperative Patient‘s and Surgeons‘ satisfaction, Intraoperative bleeding and plasma cortisol (μg/dl) postoperatively were also assessed.ResultsThere was a significant reduction in the VAS score, total pethidine requirements and significantly higher Patient‘s satisfaction in TDF and TDM groups when compared with the C group 6 h postoperatively. The sedation score and Surgeons‘ satisfaction were significantly higher associated with a significant decrease in MAP and Intraoperative bleeding in TDM group compared to groups C and TDF 6 h postoperatively. Significant nausea and vomiting in TDF group and significant sedation in TDM group were recorded.ConclusionThe use of preoperative TDF 50 μg/h or TDM 7 mg was an effective and a safe adjuvant for acute pain after surgery.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Egyptian Journal of Anaesthesia - Volume 32, Issue 3, July 2016, Pages 323–332
نویسندگان
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