کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2762276 1150707 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of prophylactic ramosetron and ondansetron on corrected QT interval during general anesthesia
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
Effects of prophylactic ramosetron and ondansetron on corrected QT interval during general anesthesia
چکیده انگلیسی

Study ObjectiveTo evaluate whether ramosetron increases the corrected QT (QTc) interval.DesignProspective, randomized, controlled study.SettingOperating room.Patients135 patients undergoing elective laparoscopic cholecystectomy.InterventionPatients were allocated to three groups to receive ondansetron 4 mg (Group O4), ramosetron 0.3 mg (Group R), or ondansetron 8 mg (Group O8). The study drugs were administered intravenously approximately 15 minutes before the end of surgery.MeasurementThe QT interval for 10 minutes after administration was recorded. The QTc interval was calculated according to the Fridericia (QTcF) formula. The primary outcome was the QTcF interval among the three groups during the 10 minutes after administration of the study drugs.Main ResultsThe QTcF interval was not significantly prolonged after administration of ondansetron 4 mg and ramosetron. It was significantly increased from one minute after administration until 7 minutes after ondansetron 8 mg (Group O8). The QTcF interval was significantly longer in Group O8 at 1, 2, 3, 4, and 5 minutes.ConclusionsThe prophylactic administration 0.3 mg of ramosetron does not increase the QTc interval. Ondansetron 8 mg increases the QTc interval more so than 4 mg of ondansetron.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Anesthesia - Volume 26, Issue 7, November 2014, Pages 511–516
نویسندگان
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