کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2762597 1150719 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pharmacogenetic workup of perioperative serotonin syndrome
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
Pharmacogenetic workup of perioperative serotonin syndrome
چکیده انگلیسی

Serotonin syndrome is gaining attention in perioperative and chronic pain settings due to the growing prevalence of multimodal therapies that increase serotonin levels and thereby heighten patient risk. A patient's genetic make-up may further increase the risk of serotonin syndrome. A case of serotonin syndrome on emergence after general anesthesia is presented. A subsequent cytochrome P4502D6 genetic test result suggested a potential alteration in metabolism. For this patient, who was taking combination antidepressant medications and receiving common perioperative medicines, additive pharmacodynamic effects converged with a pharmacogenetic predisposition, resulting in serotonin syndrome.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Anesthesia - Volume 25, Issue 8, December 2013, Pages 662–665
نویسندگان
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