کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2763064 1150738 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Liposomal encapsulation improves the duration of soft tissue anesthesia but does not induce pulpal anesthesia
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
Liposomal encapsulation improves the duration of soft tissue anesthesia but does not induce pulpal anesthesia
چکیده انگلیسی

Study ObjectiveTo compare the topical and the pulpal anesthesia efficacy of liposomal and plain benzocaine formulations.DesignDouble-blinded, randomized crossover study.SettingUniversity ambulatory dental center.Patients30 ASA physical status I volunteers.InterventionsVolunteers received, in three different sessions, topical application of liposome-encapsulated 10% benzocaine (LB10), 10% benzocaine gel (B10), and 20% benzocaine gel (B20) in the right maxillary canine mucobuccal fold.MeasurementsPain associated with the needle insertion was rated by visual analog scale (VAS) and the duration of topical anesthesia was recorded. Pulpal anesthesia was evaluated using an electric pulp tester.Main ResultsVAS values (median, 1st - 3rd quartiles) were 17 cm (11 - 25), 14 cm (3 - 22), and 21 cm (9 – 21) for B10, LB10, and B20, respectively. No differences were noted among the groups (Friedman test; P = 0.58). Soft tissue anesthesia was also not different. The LB10 [10 (8 - 12) min] showed longer soft tissue anesthesia (Friedman test; P < 0.01) than the other agents [B10 = 8 (5 - 10) min, and B20 = 7 (6 - 9) min]. None of the topical benzocaine formulations tested induced pulpal anesthesia.ConclusionsThe encapsulation of benzocaine into liposome increased the duration of soft tissue anesthesia. However, it did not induce pulpal anesthesia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Anesthesia - Volume 22, Issue 5, August 2010, Pages 313–317
نویسندگان
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