کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2764019 1150778 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of ulinastatin on pulmonary artery pressure during abdominal aortic aneurysmectomy
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
Effects of ulinastatin on pulmonary artery pressure during abdominal aortic aneurysmectomy
چکیده انگلیسی

Study ObjectiveAbdominal aortic aneurysmectomy (AAAectomy) results in a general ischemia-reperfusion syndrome accompanied by an acute rise in pulmonary artery pressure (PAP). We examined whether ulinastatin, a urinary trypsin inhibitor, prevents ischemia-reperfusion injury and increase in PAP after aortic unclamping (XU) during AAAectomy.DesignProspective study.SettingPublic, university-affiliated hospital.PatientsSixteen patients (11 males and 5 females) scheduled for AAAectomy.Interventions and MeasurementsThe patients received 300 000 IU of ulinastatin intravenously before XU (n = 8) or no additional treatment (n = 8) (control). Heart rate, central venous pressure, PAP, pulmonary arterial wedge pressure, arterial pressure, mixed venous oxygen saturation (Svo2), and cardiac output were monitored. Arterial and mixed venous blood samples were analyzed for pH, Paco2, Pao2, hemoglobin, and oxygen saturation, and the physiological shunt function (Qs / Qt) were calculated. Plasma concentrations of malondialdehyde, myeloperoxidase, granulocyte elastase, α1-antitrypsine, and thromboxane B2 and the stable hydrolysis products of thromboxane A2 were measured. Measurements were conducted before aortic crossclamping (XC) (baseline) and at 10, 30, and 60 minutes after XU.Main ResultsA significant increase in PAP was observed 10 minutes after XU in the control group but not in the ulinastatin group. At 60 minutes after XU, Qs / Qt values had increased in the control group but had decreased in the ulinastatin group. There were no significant changes in malondialdehyde, thromboxane B2, granulocyte elastase, and α1-antitrypsine levels after XU in either group. A significant decrease in the plasma level of myeloperoxidase after XU was found in both groups.ConclusionsThe present study demonstrated that ulinastatin prevents increase in PAP and shunting after XU during AAAectomy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Anesthesia - Volume 18, Issue 1, February 2006, Pages 18–23
نویسندگان
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