کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2765561 1150967 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Extravascular lung water to blood volume ratios as measures of pulmonary capillary permeability in nonseptic critically ill patients
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
Extravascular lung water to blood volume ratios as measures of pulmonary capillary permeability in nonseptic critically ill patients
چکیده انگلیسی

PurposeThe aim of this study is to evaluate the value of extravascular lung water (EVLW) to intrathoracic blood volume, global end-diastolic volume, or pulmonary blood volume ratios as a reflection of pulmonary permeability in nonseptic critically ill patients with or at risk for acute lung injury/acute respiratory distress syndrome (ALI/ARDS).MethodsPulmonary permeability was measured by the pulmonary leak index (PLI) for 67gallium-labeled transferrin and EVLW and blood volumes by the transpulmonary indicator dilution technique in 20 mechanically ventilated patients, before and after fluid loading, guided by changes in central venous pressure.ResultsNine (45%) patients had ALI/ARDS according to current criteria. The PLI was high (≥30.0 × 10−3/min) in 25% before and 30% after fluid loading. The EVLW was high (≥10 mL/kg) in 10% before and in none after fluid loading and did not increase with fluid loading, whereas blood volumes increased. Before fluid loading, PLI related to EVLW/blood volume ratios (minimum r = 0.48, P = .032). After fluid loading, PLI related to EVLW to pulmonary blood volume or intrathoracic blood volume ratios (minimum r = 0.46, P = .041). The relations were unaffected by fluid loading and pressure forces.ConclusionsThe EVLW/blood volume ratios are determined, at least in part, by moderately increased pulmonary permeability in nonseptic critically ill patients with or at risk for ALI/ARDS, independent of fluid status and pressure forces. Normal ratios may help to exclude high permeability.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Critical Care - Volume 25, Issue 1, March 2010, Pages 16–22
نویسندگان
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