کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2772740 | 1152092 | 2012 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Malignant hyperthermia – Update of diagnostics Malignant hyperthermia – Update of diagnostics](/preview/png/2772740.png)
SummaryMalignant hyperthermia (MH) is an autosomal dominant skeletal muscle disorder, associated with life threatening skeletal muscle hypermetabolism upon exposure to triggering agents, i.e. volatile anesthetics or succinylcholine. While mortality of a MH reaction used to be high, both preventive diagnostic measures and standardized treatment protocols, have led to a sharp decline of fatal MH events.Here, several established diagnostic measures are discussed, such as the clinical grading score, in-vitro caffeine/halothane contracture testing as well as genetic testing. Further, new tools like the MHApp are presented, which could prove helpful in the event of a suspected MH crisis for both the diagnostic process and the subsequent clinical action plan.
Journal: Trends in Anaesthesia and Critical Care - Volume 2, Issue 5, October 2012, Pages 218–223