کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2774342 | 1152203 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
SÃndrome de POEMS, una entidad poliglandular poco conocida. Descripción de 3 casos
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی بالینی
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چکیده انگلیسی
We report 3 patients with POEMS syndrome that illustrate the multisystemic, chronic and progressive nature of the disease. Time since onset was between 2 and 4 years. The patients complained of fatigue, lethargy, weight loss, followed by progressive weakness and skin changes. At diagnosis, all 3 patients had multiple endocrine compromise (hypothyroidism, adrenocortical insufficiency and hypogonadism).The literature highlights the frequency of endocrine abnormalities, which are present in two-thirds of patients at presentation. The most common feature is hypogonadism followed by adrenocortical insufficiency and hypothyroidism. Recognition of the components of the syndrome (neuropathy, organomegaly, endocrinopathy, M protein and skin changes) is the first step in managing the disease. Treating the endocrine compromise is essential.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: EndocrinologÃa y Nutrición - Volume 54, Issue 6, June 2007, Pages 331-334
Journal: EndocrinologÃa y Nutrición - Volume 54, Issue 6, June 2007, Pages 331-334
نویسندگان
Helard Manrique Hurtado, Cecilia Medina Sánchez, Williams Carrascal Astola, José SolÃs Villanueva, Natalia Pérez Ferré,