کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2777080 | 1152668 | 2007 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Glutathione-dependent Peroxidase Activities in Rat Submandibular Gland Glutathione-dependent Peroxidase Activities in Rat Submandibular Gland](/preview/png/2777080.png)
The activities of Se-dependent glutathione peroxidases and non-Se-dependent glutathione peroxidase in the submandibular gland were observed using specific substrates. The activities for H2O2, cumene hydroperoxide, tert-butyl hydroperoxide, and phosphatidylcholine hydroperoxide were strongly inhibited by iodoacetate. After correction for the activity toward cumene hydroperoxide, it was shown that cumene hydroperoxide is mainly reduced by cytosolic glutathione peroxidase. Although the specific activity was lower than that of cytosolic glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase showed activity toward not only phosphatidylcholine hydroperoxide but also phosphatidylethanolamine hydroperoxide. These results suggest that cytosolic glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase share a role in the reduction of hydroperoxide, but non-Se-dependent glutathione peroxidase (glutathione S-transferase) plays a lesser role.
Journal: Journal of Oral Biosciences - Volume 49, Issue 4, 2007, Pages 278-285