کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2777141 1152682 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Salivary Gland Branching Morphogenesis : Exploration of Molecular Mechanisms Using Laser Microdissection and T7-SAGE
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
Salivary Gland Branching Morphogenesis : Exploration of Molecular Mechanisms Using Laser Microdissection and T7-SAGE
چکیده انگلیسی

Branching morphogenesis is a key process utilized by many organs during embryonic development, but its mechanisms are not clearly understood. The developing submandibular salivary gland provides an excellent model system for clarifying the mechanisms comprising this phenomenon. Here we describe a recently developed set of approaches currently being used to identify and characterize molecules necessary for branching morphogenesis. The combination of laser microdissection with T7-SAGE is reviewed as a method for gene discovery of candidate molecules that may be essential for early organ morphogenesis. We describe a current approach that promises to improve our understanding of the early morphological changes that occur during branching morphogenesis. This knowledge should facilitate development of future tissue engineering techniques and approaches to regenerating branching organs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Oral Biosciences - Volume 48, Issue 1, 2006, Pages 1-6