کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2777143 | 1152682 | 2006 | 6 صفحه PDF | دانلود رایگان |
Nuclear factor-κB (NF-κB) is one of the most important transcription factors for survival, activation, and proliferation of immune cells. Main pathway of NF-κB for T cell activation is known to be NF-κB1/RelA classical pathway. Meanwhile, the role of NF-κB2/Re1B non-classical pathway is still unclear. A number of reports as to knockout mice for NF-κB subunits can lead to understand in vivo functions of NFκB. Moreover, some autoimmune models have been described in knockout and mutant mice of NF-κB genes and NF-κB-associated genes. Thus, NF-κB might be one of potent factors for pathogenesis of autoimmune diseases. This article reviews each function of NF-κB subunits as to immune system, mainly T cell activation based on our recent study and previous published studies.
Journal: Journal of Oral Biosciences - Volume 48, Issue 1, 2006, Pages 12-17