A case of a rapidly expanding odontogenic myxoma of the mandible

Odontogenic myxoma (OM) is a rare benign neoplasm with locally aggressive behavior. We present an unusual case of OM as a rapidly expanding lesion in the mandible of a 62-year-old woman who underwent segmental mandibulectomy and primary mandibular reconstruction using a titanium plate. Histologically, we observed stellate and spindle-shaped cells lying loosely in abundant mucoid stroma. Immunohistochemical staining was positive for smooth muscle actin and vimentin and negative for desmin and p53. The patient was followed up for 24 months without a recurrence. Long-term follow-up is required due to the high risk of recurrence.