کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2777215 1152689 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Recent trends in cartilage regenerative medicine and its application to oral and maxillofacial surgery
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
Recent trends in cartilage regenerative medicine and its application to oral and maxillofacial surgery
چکیده انگلیسی

Greater progress has been made in the clinical application of cartilage regenerative medicine, compared with that of other organs. A typical example of cartilage regenerative medicine is autologous chondrocyte implantation, in which chondrocytes isolated from the patient's cartilage are cultured and injected into the cartilage defects in a liquid- or gel-form. However, the classic autologous chondrocyte implantation has been applicable to only limited diseases, including focal cartilage lesion. Therefore, we developed “implant-type” tissue-engineered cartilage that shows mechanical strength and three-dimensional shape. This type of tissue-engineered cartilage uses scaffold composed of atelocollagen hydrogel and poly-l-lactic acid porous material, which is administered with cultured autologous auricular chondrocytes. Its clinical application to nasal deformity of cleft lip and palate patients has been ongoing at present. This review presents an overview of the current situation regarding cartilage regenerative medicine, as well as introducing our research and the development of implant-type tissue-engineered cartilage for the cleft-lip nose. The discussion of the future development of regenerative medicine is also mentioned.

▸ Greater progress has been made in the clinical application of cartilage regenerative medicine. ▸ This review overviews the current situation of the cartilage regenerative medicine. ▸ It also introduces our R&D of tissue-engineered cartilage for the cleft-lip nose.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Science International - Volume 10, Issue 1, January 2013, Pages 15–19
نویسندگان
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