کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2777445 | 1568009 | 2016 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Reducing dietary intake of linoleic acid of mouse dams during lactation increases offspring brain n-3 LCPUFA content Reducing dietary intake of linoleic acid of mouse dams during lactation increases offspring brain n-3 LCPUFA content](/preview/png/2777445.png)
• Reducing maternal dietary LA results in lower milk LA content.
• Increasing maternal dietary n-3 LCPUFA increases milk n-3 LCPUFA content.
• Offspring brain n-3 LCPUFA was higher following both interventions.
Omega (n-)3 and n-6 long chain polyunsaturated fatty acids (LCPUFA) accumulation in the infant brain after birth is strongly driven by dietary supply of n-3 and n-6 LCPUFAs and their C18 precursors through breast milk or infant formula. n-3 LCPUFA accretion is associated with positive effects on neurodevelopmental outcome whereas high n-6 LCPUFA accumulation is considered disadvantageous. Maternal diet is crucial for breast milk fatty acid composition. Unfortunately, global increases in linoleic acid (C18:2n-6; LA) intake have dramatically increased n-6 LCPUFA and reduced n-3 LCPUFA availability for breastfed infants. We investigated the effects of reducing maternal dietary LA, or increasing n-3 LCPUFA, during lactation on milk and offspring brain fatty acids in mice. Offspring brain n-3 LCPUFA was higher following both interventions, although effects were mediated by different mechanisms. Because of competitive interactions between n-3 and n-6 fatty acids, lowering maternal LA intake may support neurodevelopment in breastfed infants.
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Volume 110, July 2016, Pages 8–15