کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2777468 1568011 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The association between polyunsaturated fatty acid consumption and the transition to psychosis in ultra-high risk individuals
ترجمه فارسی عنوان
ارتباط بین مصرف اسید چرب اشباع نشده و انتقال به روانپریشی در افراد مبتلا به بالا بودن خطر
کلمات کلیدی
اسیدهای چرب امگا 3، اسیدهای چرب امگا 6، بررسی رژیم، وضعیت روحی در معرض خطر، جلوگیری، رژیم غذایی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
چکیده انگلیسی


• HR converters declared higher consumption of n-6 PUFA than HR non-converters and higher. consumption of linoleic acid and arachidonic acid.
• HR converters showed higher AA/(EPA+DHA) ratio than HR non-converters.
• Healthy controls declared higher consumption of n-3 PUFA than HR individuals.
• Healthy controls showed lower AA/(EPA+DHA) ratio than HR individuals.

PUFA deficiencies in cellular membranes have been observed in ultra-high risk (HR) individuals and in early schizophrenia. It is uncertain whether dietary PUFA consumption can be associated with the risk of transition to psychosis in HR individuals. The aim of the study was to assess PUFA consumption and confirm whether dietary habits are related to the risk of transition to full-threshold psychosis in HR individuals during a 12-month follow-up. PUFA consumption during the previous year was analyzed in 62 h individuals and 33 healthy controls (HC) at the beginning of the follow-up period using a validated Food-Frequency Questionnaire and the Polish Food Composition Tables. Fifteen HR individuals converted into psychosis (C-HR) during the 12-month follow-up. C-HR individuals reported significantly higher consumption of n-6 fatty acids (linoleic acid, LA and arachidonic acid, AA) in comparison with individuals who did not develop psychosis (NC-HR). The C-HR group reported a significantly higher AA/(EPA+DHA) consumption ratio than the NC-HR group. HC reported significantly higher consumption of most n-3 PUFA and lower consumption of all n-6 PUFA than both groups of HR individuals. The results suggest that dietary patterns of PUFA consumption may play a role in the conversion to psychosis of HR individuals.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Volume 108, May 2016, Pages 30–37
نویسندگان
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